Purpose
The purpose of this lab was to take the disease we chose and to identify what protein is affected and what it changes about the body.
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Thinking and behavioral problems may also occur. Dementia becomes common in the advanced stages of the disease. Depression and anxiety are also common occurring in more than a third of people with PD. Other symptoms include sensory, sleep, and emotional problems. The main motor symptoms are collectively called "parkinsonism", or a "parkinsonian syndrome". (Wikipedia)
The movement difficulties found in PD are called "parkinsonism" and a number of different disorders feature parkinsonism. "Parkinsonism" is defined as bradykinesia.
Disease info:
-Seligiline - Anti-depressant
-Rivastigmine - Treats Dementia
-Benztropine - Anti-Tremor
The DNA is the template. RNA polymerase takes DNA and unzipped double helix. Separates both sides and replaces one side with mRNA. This is known as Transcription. Transcription occurs in the nucleus. Then it moves out into the cytoplasm. Amino Acid bond with tRNA.The tRNA prongs are known as anti codons and the mRNA prongs are known as codons. tRNA attaches to mRNA. mRNA with tRNA are fed through the ribosomes and the amino acids are connected to form long line chains called polypeptide chains. Those polypeptide chains are folded into alpha helix or beta sheets. Many alpha helix and beta helix come together and are form domains in the and the then form proteins. This is the process known as Translation.
The reference sequence of the mRNA for parkinson's is GCG UCU CCG UGG CGG GGU UCA and the reference for the protein is
Cgc Aga Ggc Acc Gcc Cca Agt. The amino acid sequence ALA SER PRO TRP ARG GLY SER.
Reflection
The first good thing about this project was that we were pretty independent for most of it. This was because we all had things to work on and we all had things to research. The second thing that was good was that we managed our time a lot better with the help of the gant chart.
The first bad thing about this project was that the subject matter was rather bland and wasn't too interesting. My opinion is of course tilted because I am not a huge fan of biology and bio tech. The second bad thing was that the subject matter that the project was based upon was rather complicated which normally wouldn't be too bad but it took many more times than I would have liked to call someone over to clarify something.
The movement difficulties found in PD are called "parkinsonism" and a number of different disorders feature parkinsonism. "Parkinsonism" is defined as bradykinesia.
Disease info:
- What is it - Parkinson's disease is a long-term disorder occurring in the central nervous system that affects movement, that may include trembling. PINK1 is being misprogrammed to target serine/threonine kinase domains.
- What parts of the body does it affect, symptoms - This affects the motor (or movement) system. Some symptoms are shaking, difficulty with walking, dementia, depression, and sleep and emotional problems.
- What protein is affected - PINK1 protein.
- Who is likely to get it - Advancing age, sex (men are more likely), Family History, Agricultural Work, Genetic Factors, Head Trauma, and many more.
- What are the treatments or cures?
-Seligiline - Anti-depressant
-Rivastigmine - Treats Dementia
-Benztropine - Anti-Tremor
The DNA is the template. RNA polymerase takes DNA and unzipped double helix. Separates both sides and replaces one side with mRNA. This is known as Transcription. Transcription occurs in the nucleus. Then it moves out into the cytoplasm. Amino Acid bond with tRNA.The tRNA prongs are known as anti codons and the mRNA prongs are known as codons. tRNA attaches to mRNA. mRNA with tRNA are fed through the ribosomes and the amino acids are connected to form long line chains called polypeptide chains. Those polypeptide chains are folded into alpha helix or beta sheets. Many alpha helix and beta helix come together and are form domains in the and the then form proteins. This is the process known as Translation.
The reference sequence of the mRNA for parkinson's is GCG UCU CCG UGG CGG GGU UCA and the reference for the protein is
Cgc Aga Ggc Acc Gcc Cca Agt. The amino acid sequence ALA SER PRO TRP ARG GLY SER.
Reflection
The first good thing about this project was that we were pretty independent for most of it. This was because we all had things to work on and we all had things to research. The second thing that was good was that we managed our time a lot better with the help of the gant chart.
The first bad thing about this project was that the subject matter was rather bland and wasn't too interesting. My opinion is of course tilted because I am not a huge fan of biology and bio tech. The second bad thing was that the subject matter that the project was based upon was rather complicated which normally wouldn't be too bad but it took many more times than I would have liked to call someone over to clarify something.